Joint Health

When your PRP is Photo-Activated (PAPRP) you jump-start the natural healing cascade

The PAPRP procedure is simple. Your blood is withdrawn as usual, spun in a centrifuge and the PRP is collected from the top of the Tubes, which contain an anticoagulant, and then transferred into a syringe. After this standard procedure, your doctor places the syringe into the chamber of AdiLight-2 for an extra 10 minutes to photoActivate the PRP (see the procedure described on the other side of this leaflet).

The process has now been widely shown to significantly reduce joint pain and accelerate healing. PAPRP adds AdiLight-2’s anti-inflammatory benefits of photoActivation to the PRP, which is concentrated source of platelets rich in growth factors, and cytokines that accelerate and enhance the healing of bone and soft tissue.

For patients this means two things. The aggravated pain of a standard PRP procedure in the affected area is significantly reduced by the photoActivation process which reduces inflammation, increases the production of natural pain killers and releases beta endorphins. This means relief from pain in a couple of days – rather than in weeks or months if photoActivation is not used.

The PAPRP Therapy has also been found to stimulate cartilage and tissue repair and to reduce pain and inflammation to the extent of either delaying invasive surgery – or even making it unnecessary.

Note: PhotoActivated PRP (PAPRP) is also being used successfully in cosmetic and aesthetic procedures for facial rejuvenation – and for hair loss via injection into the scalp.

Doctors are now using AdLight-2 PAPRP in 46 Countries.

Platelet contains growth factors and release Bio-activate proteins

Studies indicate that platelets contain over 400 growth factor components and cytokines that are crucial in soft tissue healing and bone regeneration.

Research shows that platelets also release many bioactive proteins responsible for attracting macrophages, mesenchymal stem cells and osteoblasts that not only promote removal of degenerated and necrotic tissue, but also enhance tissue regeneration and healing.

PRP and PAPRP Processes are Autologous

PRP/PAPRP is inherently safe because the cells, which heal, are not taken from another human being or an animal. They are your own cells taken from your own body-and used to repair your own body.

Since PRP is an autologous concentration of platelets in a small volume plasma taken from your own blood, there are no contraindications or adverse side effects.

Growth factors also have a role in signalling mesenchyme stem cells to proliferate and differentiate inside the area to be repaired. They act like “homing signals”.

Thousands of Research Articles have been published on the safety and efficacy of the PRP Procedure over the past 30 years.

The PRP procedure itself is approved by the FDA.

Why Photo-Activation Works?

AdiStem has researched the effect of different monochromatic light intensities and frequencies in the coloured spectrum on human and animal cell populations such as mesenchyme stem cell and white blood cells. Through the use of three colour spectrums (red, yellow and green at particular frequencies), white blood cells are signalled to release IL-IRA and beta-endorphins. Interleukin I Receptor Antagonist is a potent anti-inflammatory agent and reduces the pain associated with standard PRP injections. The duration of any pain is also significantly reduced.

In other words, the use of PhotoActivation stimulates other regenerative cells which jump-starts the natural healing cascade. Inflammation is reduced, the production of natural painkillers is increased and additional mesenchyme stem cells are recruited to help the area of injury.

The PhotoActivation process adds only 10 minutes to the normal PRP procedure.

What leading doctors are saying about benefits of Photo-Activating PRP (PAPRP):

Dr Steven Sampson: Founder of the Orthohealing Centre, USA. He created the Orthobiologic Institute (T0B1) and chairs and moderates an Annual Regenerative Medicine Symposium featuring foremost experts in tendon and cartilage disease.

“The AdiStem PhotoActivation Technology facilitates less post injection discomfort and flare-ups with a more rapid recovery. This technology represents the next level in regenerative medicine providing a more customized approach to biologic based therapies like PRP”.

Dr. Adam Weglein D.O.: Founder of the Regenerative Ortho Med Institute, USA. Professor, University of Texas, Houston Medical School.

“I have been doing PRP Treatments for the past 6 years. I have been very pleased with the additional of the AdiLight-2 PhotoActivation system, noticing an enhanced healing rate with less post injection pain”.

Dr Julien Freitag. Published December 2012 in the British Medical Journal on ” PAPRP Therapy for a Traumatic Knee Contrail Lesion”. He evaluated the effect of combining PhotoActivation therapy (using AdiLight-2) with PRP injections in the treatment of a traumatic knee contrail lesion. The patient reported 100% improvement in both pain and function as measured by the Numerical Pain Rating Scale and the WOMAC Knee Score. No Complications were noted. For the full research paper refer to BMJ website. As second Report on PAPRP for Osteoarthritis was published in BMJ, March 26.2013. A 40 Patient trial is now being planned.

Dr Joseph Purita is Head of the Institute of Regenerative & Molecular Orthopaedics, Fellow of the American Academy of Orthopaedic Surgeons and the American College of Surgeons. He lectures internationally on PRP and Stem Cell Therapy. “I have now done thousand of cases with AdiLight. I now don’t do one case without it.”

Healing of your musculoskeletal pain is accelerated and pain is reduced when your PRP is Photo-activated (PAPRP) for:

  • Osteoarthritis
  • Knees
  • Neck
  • Lower Back
  • Hip
  • Elbow and Small Joints
  • Muscle Tears and sprains
  • Tendon Injuries
  • Ligaments Injuries
  • Spine and shoulder Disorders
  • Rotator Cuff Tears
  • Chronic Plantar Fasciitis
  • Bursitis-and other Painful Musculoskeletal Disorders

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Normal Protocol: One injection per week for 3 weeks. Total 3 injections (3 visits) followed by a Review Consultation 4 weeks after the Third Injection. Sometimes a 4th Injection is beneficial.

Step 1: Withdraw Blood and Prepare PRP

4 AdiStem PRP Tubes are filled with Patient’s Blood

Step 2 : Centrifugation

  • The blood is then placed in a Centrifuge for 10 Minutes at 200 RCG. Tubes are placed opposite each other to balance.
  • Blood will fractionate. PRP will be on top and Red Blood Cell at bottom.

Step 3 : Aspirate PRP and PhotoActivate

  • Right after centrifugation, a 10ml Syringe and an 18g Needle is used to Draw up/Aspirate the PRP and “Buffy Coat”.
  • PRP is collected from all Tubes, and then placed in a Syringe in the AdiLight-2 for 10 minutes to PhotoActivate.
  • The PAPRP is now ready to inject using a 5ml Syringe. Only when necessary an Ultrasound guided injection can be used to ensure PRP is placed exactly into the injured tissue.

Contact PrimaNora Medical Centre if you wish to know more about how you can have PRP Photo-Activated and discuss what this can do for you.

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